Kuo-Ching Wen

Adjunct Faculty

 
NAME

Kuo-Ching Wen
TITLE

Emeritus Professor
AFFILIATION

E-mail: kcwen0520@mail.cmu.edu.tw
EDUCATION

Ph.D., National Osaka University, Japan
FIELDS OF
SPECIALTY
  1. Development of analytic methods for herbal medicines
  2. Development of analytic methods for Drugs and Cosmetics
  3. Research and development of functional cosmetics (whitening agents, antioxidants, anti-aging agents)
  4. Regulation on Drugs and Cosmetics
RESEARCH INTERESTS
  1. Development of analytic methods for herbal medicines
  2. Development of analytic methods for Drugs and Cosmetics
  3. Research and development of functional cosmetics (whitening agents, antioxidants, anti-aging agents)
  4. Regulation on Drugs and Cosmetics
GRANTS
  • The investigation on isolating active constituents and preparing lipids nanoparticles of Flemingia macrophylla and the effects and their mechanisms for anti-photoaging and anti-photocarcinogenesis (NSC99-NSC99-2320-B-039-012-MY3)
  • The investigation on preparations of Ampelopsis japonica, Vitis vinifera x-Vitis labrus Cal. and their active constituents and their mechanisms for anti-photoaging and anti-photocarcinogenesis (CCMP)
PUBLICATIONS

  Research papers

  1. MJ Wang, PD Chao, YC Hou, SL Hsiu, KC Wen, SY Tsai. Phmacokinetics and conjugation metabolism of naringin and naringenin in rats after single dose and multiple dose administrations. J Food Drug Anal 14: 166-173, 2006. (SCI)
  2. MJ Wang, YC Hou, SY Tsai, SL Hsiu, KC Wen, PD Chao. Effects of coadministrations of unripe fruits and ripe peels of Citrus aurantium on cyclosporine pharmacokinetics in rats. J Food Drug Anal 15: 265-270, 2007. (SCI)
  3. HM Chiang, HT Tsao, PD Chao, YC Hou, KC Wen. Determination of anthraquinone glycosides in Rhei Rhizome, Polygoni Multiflori Radix, and Cassia Torae Semen. J Food Drug Anal 15(4): 447-457, 2007. (SCI)
  4. CW Lin, HM Chiang, YC Lin, KC Wen. Natural products with skin-whitening effects. J Food Drug Anal 16(2): 1-10, 2008. (SCI)
  5. PP Fu, HM Chiang, Q Xia, T Chen, JJ Yin, KC Wen, G Lin, H Yu. Quality assurance and safety of herbal dietary supplements. J Environ Sci Health. Part C. 27: 91-119, 2009. (SCI)
  6. HM Chiang, SY Tsai, PL Hsiao, CY Chiu, SL Hsiu, KC Wen. Determination of total polyphenol glycosides in Polygoni cuspidati rhizoma and Rumecis radix. J Chin Chem Soc 56: 341-350, 2009. (SCI)
  7. KC Wen, SP Lin, CP Yu, HM Chiang. Comparison of Puerariae radix and its hydrolysate on stimulation of hyaluronic acid production in NHEK cells. Amer J Chin Med 38: 143-155, 2010. (SCI)
  8. HM Chiang, JJ Yin, Q Xia, Y Zhao, PP Fu, KC Wen, H Yu. Photoirradiation of azulene and guaiazulene – Formation of reactive oxygen species and induction of lipid peroxidation. Journal of Photochemistry and Photobiology A: Chemistry, 211:123-128, 2010. (SCI)
  9. Hsiu-Mei Chiang, YL Ko, IC Shih, KC Wen. Development of Wine Cake as a Skin-Whitening Agent and Humectant. Journal of Food and Drug Analysis. 2010 (accepted)
  10. KC Wen, SL Chan, IL Liu, PY Lai, YT Lin, SL Hsiu, HM Chiang. Development and validation of an HPLC method for the simultaneous determination of marker compounds of Aloe and Scutellariae radix in cosmetics. Journal of Food and Drug Analysis. 15:328-338, 2010 (SCI)
  11. HM Chiang, JW Lin, PL Hsiao, SY Tsai, KC Wen. Hydrolysates of citrus plants stimulate melanogenesis protecting UV-induced dermal damage. Phytotherapy Research 2010. (in press)
  12. HM Chiang, TJ Lin, CY Chiu, CW Chang, KC Hsu, PC Fan, KC Wen. Coffea arabica extract and its constituents prevent photoaging by suppressing MMPs expression and MAPK pathway. Food Chem Toxicol 2010 (accepted).
  13. KC Wen, IC Shih, JC Hu, ST Liao, TW Su, Hsiu-Mei Chiang. Inhibitory effects of Terminalia catappa on UVB-induced photo-damage in fibroblast cell line. Evidence-Based Complementary and Alternative Medicine, 2010 (accepted).

  Conference papers

  1. Hsiu-Mei Chiang, Ssu-Meng Wang, I-Chen Shih, Kuo-Ching Wen. The effects and mechanisms of Neonauclea reticulate on anti-photoaging. 10th ASCS (Asian Society of Cosmetic Scientists) conference, Seoul, Korea. Apr. 6-8, 2011.
  2. Kuo-Ching Wen, Sue-Tsai Liao, Pei-Ching Fan, Hsiu-Mei Chiang. The effects and mechanisms of Flemingia macrophylla on anti-photoaging. 10th ASCS (Asian Society of Cosmetic Scientists) conference, Seoul, Korea. Apr. 6-8, 2011.
  3. Hsiu-Mei Chiang, Yin-Chih Chien, Wan-Chen Wu, Yu-Yun Pan, Shih-Mei Wu, Kuo-Ching Wen. Inhibition of Melanogenesis by Rhodiola rosea and Its Hydrolysate via Regulation of CREB, ERK and AKT in B16F0 Cells. The 57th Annual Meeting of the Japan Society of Pharmacognosy (Tokushima, 2010), and The 5th JSP-CCTNM-KSP Joint Symposium on Pharmacognosy, Tokusima, Japan. Sep. 23-26, 2010.
  4. Kuo-Ching Wen, I-Chen Shih, Jhe-Cyuan Hu, Sue-Tsai Liao, Tsung-Wei Su, Chien-Wen Chen, Hsiu-Mei Chiang. Terminalia catappa L. extract attenuates UVB-induced MMPs expression via the MAPKs pathway. The 57th Annual Meeting of the Japan Society of Pharmacognosy (Tokushima, 2010), and The 5th JSP-CCTNM-KSP Joint Symposium on Pharmacognosy, Tokusima, Japan. Sep. 23-26, 2010.
  5. Qingsu Xia, Hsiu-Mei Chiang, Hongtao Yu, Jun Jie Yin, Fu P Peter. In vitro cytotoxicity and generation of oxidative stress by zinc oxide nanoparticles in human and rodent cells. 240th American Chemical Society National Meeting & Exposition, Boston, USA, Aug. 22-26, 2010.
  6. Pei-Ching Fan, Hsiu-Mei Chiang, Shu-Ling Chan, Su-Lan Hsiu, Kuo-Ching Wen. Determination of the Components of Aloe in Cosmetics. 238th American Chemical Society National Metting & Exposition, Washington, DC, USA, Aug. 16-20, 2009.
  7. Kuo-Ching Wen, Tsen-Jung Lin, Yin-Chih Chien, I-Chen Shih, Hsiu-Mei Chiang. Inhibitory effects of Michelia alba on matrix metalloproteinases expression in UVB-irradiated human skin fibroblasts. 238th American Chemical Society National Metting & Exposition, Washington, DC, USA, Aug. 16-20, 2009.
  8. Yin-Chih Chien, Hui-Ting Tsao, I-Chen Shih, Shu-Han Fan, Hsiu-Mei Chiang, Kuo-Ching Wen*. The skin whitening effect of Rhodiola rosea. The International Congress of the IFSCC (International Federation of Societies of Cosmetic Chemists), Barcelona, Spain, Oct. 6-9, 2008.
  9. Chen-Yuan Chiu, Tsen-Jung Lin, Yin-Chih Chien, Yu-Tzu Liu, Tsan-Chun Wu, Kuo-Ching Wen, Hsiu-Mei Chiang. Effects and mechanisms of Coffea arabica extraction on collagen synthesis. The International Congress of the IFSCC (International Federation of Societies of Cosmetic Chemists), Barcelona, Spain, Oct. 6-9, 2008.
  10. Tsen-Jung Lin, Kuo-Ching Wen, Hsiu-Mei Chiang. Establishment of platform for determining dermatopharmacokinetics of Chinese herbs - Rheum palmatum L. and Rumex japonicus Houtt. as examples. International Investigative dermatology 2008. Kyoto, Japan. May 14-17, 2008.
  11. Hui-Ting Tsao, Hsiu-Mei Chiang, Kuo-Ching Wen* The effects of Paeoniae lactiflorae radix decoction and its hydrolysates on melanin. International Investigative ermatology 2008. Kyoto, Japan. May 14-17, 2008.
  12. Yi-Ling Ko, Chung-Lan Yu, Hsiu-Mei Chiang, Kuo-Ching Wen. Exploring Mechanisms of the Whitening Effect of KC-5TA and KC-5TB, Extracts of Psychotria serpens L. Pharmaceutical Sciences world Congress. Amsterdam, Netherlands, April 21-25, 2007.
  13. Hui-Ting Tsao, Pei-Ling Hsiao, Hsiu-Mei Chiang, Kuo-Ching Wen. Quality Control of Polyphenol Glycosides Contents in Chinese Herbs. Pharmaceutical Sciences world Congress. Amsterdam, Netherlands, April 21-25, 2007
  14. Yen-Jen Wang, Yu-Chi Hou, Kuo-Ching Wen, Hsiu-Mei Chiang, Shang-Yuan Tsai. The Tyrosinase-inhibit Activity of some Fruit Extract. Pharmaceutical Sciences world Congress. Amsterdam, Netherlands, April 21-25, 2007