Chia-Lin Lee

Full-Time Faculty

 
NAME

Chia-Lin Lee
TITLE

Associate Professor
AFFILIATION

Tel: +886-4-22053366 ext 5806

E-mail: chlilee@mail.cmu.edu.tw
EDUCATION

Ph.D., Graduate Institute of Natural Products, Kaohsiung Medical University
FIELDS OF
SPECIALTY
  1. New Drug Development of Chinese Medicines
  2. Natural Products Chemistry
RESEARCH INTERESTS

Drug development of traditional Chinese medicine (TCM) for treatment and prevention of skin disorders
GRANTS
  1. MOST 105-2320-B-039-047-MY3
  2. MOST 103-2320-B-039-003-MY2
  3. NSC 100-2113-M-039-003
PUBLICATIONS

  Research papers

  1. I-Ting Weng, Yen-An Lin, Guan-Yu Chen, Hsiu-Mei Chiang, Yi-Jung Liu, Chao-Jung Chen, Yu-Hsuan Lan, Chia-Lin Lee*, (–)-β-Homoarginine anhydride, a new antioxidant and tyrosinase inhibitor, and further active components from Trichosanthes truncate. Nat. Prod. Res. 2018 Accepted
  2. Kuan-Ying Lai, Hao-Chun Hu, Hsiu-Mei Chiang, Yi-Jung Liu, Juan-Cheng Yang, Yen-An Lin, Chao-Jung Chen, Yuan-Shiun Chang, Chia-Lin Lee*, New diterpenes leojaponins G–L from Leonurus japonicas. Fitoterapia 2018, 130, 125−133.
  3. I-Hsiao Chen, Ming-Yi Yang, Shin-Hun Juang, Chia-Lin Lee, Tran-Dinh Thang, Mohamed EI-Shazly, Yu-Hsuan Lan* Bioactive components of Fissistigma cupreonitens. Nat. Prod. Commun. 2018, 13, 679−682.
  4. Chia-Lin Lee, Shou-Lun Lee, Chao-Jung Chen, Hsin-Chun Chen, Ming-Ching Kao, Chuan-Hao Liu, Jau-Yang Chen, Yen-Ting Lai, Yang-Chang Wu* Characterization of secondary metabolites from purple Ipomoea batatas leaves and their effects on glucose uptake. Molecules 2016, 21, 745; doi:10.3390/molecules21060745.
  5. Ching-Chia Li, Juan-Cheng Yang, Medi-Chin Lu, Chia-Lin Lee, Chieh-Yu Peng, Wei-Yu Hsu, Yun-Hao Dai, Fang-Rong Chang, Da-Yong Zhang, Wen-Jeng Wu,* Yang-Chang Wu* ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer. Oncotarget. 2016, 7, 1947−1959.
  6. Chieh-Yu Peng, Bang-Jau You, Chia-Lin Lee, Yang-Chang Wu, Wen-Hsin Lin, Te-Ling Lu, Fei-Ching Chang, Hong-Zin Lee* The roles of 4β-hydroxywithanolide E from Physalis peruviana on the Nrf2-antioxidant system and cell cycle in breast cancer cells. Am. J. Chin. Med. 2016, 44, 617−636.
  7. Ching-Peng Chiu, Shan-Chi Liu, Chih-Hsin Tang, You Chan, Mohamed EI-Shazly, Chia-Lin Lee, Ying-Chi Du, Tung-Ying Wu, Fang-Rong Chang,* Yang-Chang Wu* Anti-inflammatory cerebrosides from cultivated Cordyceps militaris. J. Agric. Food Chem. 2016, 64, 1540−1548.
  8. Chia-Lin Lee, Tsong-Long Hwang, Chieh-Yu Peng, Chao-Jung Chen, Chao-Lin Kou, Wen-Yi Chang, Yang-Chang Wu* Anti-inflammatory and cytotoxic compounds from Solanum macaonense. Nat. Prod. Commun. 2015, 10, 345−348.
  9. Chia-Lin Lee,* Ming-Hon Yen, Tsong-Long Hwang, Juan-Cheng Yang, Chieh-Yu Peng, Chao-Jung Chen, Wen-Yi Chang, Yang-Chang Wu Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia. Phyto. Lett. 2015, 12, 237−242.
  10. Chieh-Yu Liao, Chia-Lin Lee, Hui-Chun Wang, Shih-Shin Liang, Po-Hsiung Kung, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung Wu* CLL2-1, a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-1 (CalDAG-GEFI). Free Radic. Bio. Med. 2015, 78, 101−110.
  11. Jung-Chun Liao, Kun-Tsung Lee, Bang-Jau You, Chia-Lin Lee, Wen-Te Chang, Yang-Chang Wu, Hong-Zin Lee* Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration. Food Nutr. Res. 2015, 59, 29884.

  Conference papers

  1. Anti-melanogenesis and antioxidant components from Ampelopsis japonica, The 33th Symposium on Natural Products, Kaohsiung/Taiwan, 2018.10.06-2018.10.07
  2. New indole alkaloids from Qing Dai, , The 33th Symposium on Natural Products, Kaohsiung/Taiwan, 2018.10.06-2018.10.07
  3. Secondary metabolites isolated from Pharbitis nil, The 33th Symposium on Natural Products, Kaohsiung/Taiwan, 2018.10.06-2018.10.07
  4. Anti-melanogenesis LJMEH from Leonurus japonicus, The 33th Symposium on Natural Products, Kaohsiung/Taiwan, 2018.10.06-2018.10.07
  5. Anti-metastatic and anti-allergic spirostanol saponins from Solanum macaonense and S. torvum, 65th Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Basel/Switzerland, 2017.9.3-2017.9.7
  6. Anti-melanogenesis components from Leonurus japonicas, 65th Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Basel/Switzerland, 2017.9.3-2017.9.7
  7. The components isolated from active LJMWB crude fraction of Leonurus japonicas, The 32th Symposium on Natural Products, Taichung/Taiwan, 2017.10.13- 2017.10.14
  8. Chemical profile analysis and active components from the root of Cynara scolymus. The 29th Symposium on Natural Products, Taichung/Taiwan, 2017.10.13- 2017.10.14
  9. Anti-melanogenesis components from traditional Chinese medicine, Pharbitidis Semen, The 9th China Medical University and Asia University Joint Conference on Biotechnology, Taichung/Taiwan, 2016.3.14 -2016.3.14
  10. Developing anti-melanogenesis agents from a traditional Chinese medicine, Leonurus japonicas, The 31th Symposium on Natural Products & Symposium of Pharmacy and Traditional Chinese Medicine, Kaohsiung/Taiwan, 2016.10.14- 2016.10.15
  11. Anti-glucose uptake secondary metabolites from purple Ipomoea batatas leaves, The 31th Symposium on Natural Products & Symposium of Pharmacy and Traditional Chinese Medicine, Kaohsiung/Taiwan, 2016.10.14 ~ 2016.10.15
  12. Antineutrophilic inflammatory secondary metabolites from Solanum macaonense, 63rd GA, Budapest/Hungary, 2015.8.23- 2015.8.27
  13. Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia, The 29th Symposium on Natural Products, Kaohsiung/Taiwan, 2014.9.27-2014.9.28
  14. Bioactive steroidal glycosides from Solanum torvum, 2012 International Congress on Natural Products Research, New York/USA, 2012.7.28-2012.8.1
  15. Anti-neutrophilic inflammatory secondary metabolites from traditional Chinese medicine, Tiankuizi, The 27rd Symposium on Natural Products, Kaohsiung/Taiwan, 2012.10.6-2012.10.7
  16. Cytotoxic and antiplatelet aggregation metabolites from Calanthe arisanensis, 52nd Annual Meeting of the American Society of Pharmacognosy, San Diego/USA, 2011.7.30-2011.8.3