Faculty


NAME
    Po-Chen Chu
TITLE
    Assistant professor
AFFILIATION
EDUCATION
    Ph.D., Institute of Biochemical Sciences National Taiwan University, Taipei, Taiwan
FIELDS OF
SPECIALTY
  • Molecular Biology
  • Cell Biology
  • Cancer Biology
  • Signal transduction
RESEARCH INTERESTS
  • Cancer metastasis
  • The role of microRNAs in cancer growth and metastasis
  • Hsp70 inhibitor
GRANTS
  1. MOST   106-2320-B-001-012-MY3  08/01/2017 ~ 07/31/2020 (PI)
  2. Title: Targeting PAK3 to eradicate pancreatic cancer stem cells by suppressing Wnt/beta-catenin signaling

  3. MOST   105-2320-B-001-004           08/01/2016 ~ 07/31/2017 (PI)
  4. Title: Study the role of oncogenic KRAS/miR-137 signaling axis in colorectal cancer liver metastasis

  5. NHRI    NHRI-EX105-10521BI       01/01/2016 ~ 12/31/2018 (co-PI)
  6. Title: Targeting HDAC 8 to eradicate breast cancer stem cells by suppressing Notch1 signaling

  7. MOST   103-2320-B-001-017           08/01/2014 ~ 07/31/2015 (PI)
  8. Title: Targeting a Novel KRAS-Integrin-Linked Kinase Regulatory Circuitry in Pancreatic Cancer

Publications

Research papers

  1. Peng-Chan Lin, Hao-Yu Hsieh, Po-Chen Chu, and Ching S. Chen (2018, Jul). Therapeutic Opportunities of Targeting Histone Deacetylase Isoforms to Eradicate Cancer Stem Cells. International Journal of Molecular Sciences, 19(7), 1939. (IF: 3.226; SCI, 54/166, CHEMISTRY, MULTIDISCIPLINARY).
  2. Po-Chen Chu, Peng-Chan Lin, Hsing-Yu Wu, Kuen-Tyng Lin, Christina Wu, Tanios Bekaii-Saab, Yih-Jyh Lin, Chung-Ta Lee, Jeng-Chang Lee, Ching-Shih Chen (2018, Jun). Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway. Oncogene, 37(25):3440-3455. (IF: 7.519; SCI, 21/217, ONCOLOGY).
  3. Li-Yuan Bai, Chang-Fang Chiu, Shih-Jiuan Chiu, Po-Chen Chu & Jing-Ru Weng (2017, Jul). FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma cells, in part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism. Scientific Reports, 7(1):5600. (IF: 4.259; SCI, 10/64, MULTIDISCIPLINARY SCIENCES).
  4. Han-Li Huang, Hsing-Yu Wu, Po-Chen Chu, I-Lu Lai, Po-Hsien Huang, Samuel K. Kulp, Shiow-Lin Pan, Che-Ming Teng, Ching-Shih Chen (2017, Jul). Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells. Oncogenesis, 6(7):e359. (IF: 4.143; SCI, 62/217, ONCOLOGY).
  5. Wan-Chi Tsai, Li-Yuan Bai, Yi-Jin Chen, Po-Chen Chu, Ya-Wen Hsu, Aaron M. Sargeant, Jing-Ru Weng (2017, Apr). OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling. Oncotarget, 8(17):29233-29246. (IF: 5.168; SCI, 44/217, ONCOLOGY).
  6. Po-Hsien Huang, Pei-Jung Lu, Li-Yun Ding, Po-Chen Chu, Wei-Yu Hsu, Chang-Shi Chen, Chih-Chieh Tsao, Bo-Heng Chen, Chung-Ta Lee, Yan-Shen Shan, and Ching-Shih Chen (2017, Apr). TGFb promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1. Oncogene, 36(16):2202-2214. (IF: 7.519; SCI, 21/217, ONCOLOGY).
  7. Po-Chen Chu, Samuel K. Kulp, Tanios Bekaii-Saab, and Ching-Shih Chen (2016, Dec). Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer. Small GTPases, Dec 9:1-5.
  8. Po-Chen Chu, Ming-Chen Yang, Samuel K. Kulp, Santosh B. Salunke, Lauren E. Himmel, Chun-Sheng Fang, Appaso M. Jadhav, Yan-Shen Shan, Chung-Ta Lee, Ming-Derg Lai, Lawrence A. Shirley, Tanios Bekaii-Saab, and Ching-Shih Chen (2016, Jul). Regulation of oncogenic KRAS signaling via a novel KRAS integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells. Oncogene, 35(30):3897-3908. (IF: 7.519; SCI, 21/217, ONCOLOGY).
  9. Peng-Chan Lin, Yi-Fang Yang, Yu-Chang Tyan, Eric S. L. Hsiao, Po-Chen Chu, Chung-Ta Lee, Jenq-Chang Lee, Yi-Ming Arthur Chen, Pao-Chi Liao (2016, Jul). Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses. PLoS One, 11(7):e0158844. (IF: 2.806; SCI, 15/64, MULTIDISCIPLINARY SCIENCES).
  10. Chia-Hsien Wu, Li-Yuan Bai, Ming-Hsui Tsai, Po-Chen Chu, Chang-Fang Chiu, Michael Yuanchien Chen, Shih-Jiuan Chiu, Jo-Hua Chiang & Jing-Ru Weng (2016, Jun). Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents-A drug repurposing strategy. Scientific Reports, 6:27540. (IF: 4.259; SCI, 10/64, MULTIDISCIPLINARY SCIENCES).
  11. Li-Yuan Bai, Chang-Fang Chiu, Po-Chen Chu, Wei-Yu Lin, Shih-Jiuan Chiu & Jing-Ru Weng (2016, Mar). A triterpenoid from wild bitter gourd inhibits breast cancer cells. Scientific Reports, 6:22419. (IF: 4.259; SCI, 10/64, MULTIDISCIPLINARY SCIENCES).
  12. Min-Wu Chao, Po-Chen Chu, Hsiao-Ching Chuang, Fang-Hsiu Shen, Chih-Chieh Chou, En-Chi Hsu, Lauren E. Himmel, Han-Li Huang, Huang-Ju Tu, Samuel K. Kulp, Che-Ming Teng, Ching-Shih Chen (2016, Jan). Non-epigenetic Function of HDAC8 in Regulating Breast Cancer Stem Cells by Maintaining Notch1 Protein Stability. Oncotarget, 7(2):1796-1807. (IF: 5.168; SCI, 44/217, ONCOLOGY).
  13. Chi-Fang Chang#, Po-Chen Chu#, Pei-Yu Wu, Ming-Ying Yu, Jin-Yu Lee, Ming-Daw Tsai, Mau-Sun Chang (2015, Apr). PHRF1 promotes genome integrity by modulating non-homologous end-joining. Cell Death and Disease, 6:e1716. (IF: 5.965; SCI, 39/190, CELL BIOLOGY). (# Equal Contribution).
  14. Lisa D. Berman-Booty, Po-Chen Chu, Jennifer M. Thomas-Ahner, Brad Bolon, Dasheng Wang, Tiffany Yang, Steven K. Clinton, Samuel K. Kulp, and Ching-Shih Chen (2013, Mar). Suppression of prostate epithelial proliferation and lesion progression in transgenic mice by a novel energy restriction-mimetic agent. Cancer Prevention Research, 6(3):232-241. (IF: 5.021; SCI, 67/217, ONCOLOGY).
  15. Po-Chen Chu, Hsiao-Ching Chuang, Samuel K. Kulp, and Ching-Shih Chen (2012, Dec). The mRNA-stabilizing factor HuR protein is targeted by b-TrCP protein for degradation in response to glycolysis inhibition. The Journal of Biological Chemistry, 287(52):43639-43650. (IF: 4.125; SCI, 74/286, BIOCHEMISTRY & MOLECULAR BIOLOGY).
  16. Shuo Wei, Po-Chen Chu, Hsiao-Ching Chuang, Wen-Chun Hung, Samuel K. Kulp, Ching-Shih Chen (2012, Oct). Targeting the Oncogenic E3 Ligase Skp2 in Prostate and Breast Cancer Cells with a Novel Energy Restriction-Mimetic Agent. PLoS One, 7(10):e47298. (IF: 2.806; SCI, 15/64, MULTIDISCIPLINARY SCIENCES).
  17. Chia-Hsin Chen#, Po-Chen Chu#, Liekyeow Lee, Huang-Wei Lien, Tse-Ling Lin, Chi-Chen Fan, Peter Chi, Chang-Jen Huang, Mau-Sun Chang (2012, Mar). Disruption of Murine mp29/Syf2/Ntc31 Gene Results in Embryonic Lethality with Aberrant Checkpoint Response. PLoS One, 7(3):e33538. (IF: 2.806; SCI, 15/64, MULTIDISCIPLINARY SCIENCES). (# Equal Contribution).
  18. Chun-Han Chen, Po-Hsien Huang, Po-Chen Chu, Mei-Chuan Chen, Chih-Chien Chou, Dasheng Wang, Samuel K. Kulp, Che-Ming Teng, Qianben Wang and Ching-Shih Chen (2011, Mar). Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. The Journal of Biological Chemistry, 286(12):9968-9976. (IF: 4.125; SCI, 74/286, BIOCHEMISTRY & MOLECULAR BIOLOGY).
  19. Hao-Yen Chang, Chi-Chen Fan, Po-Chen Chu, Bo-En Hong, Hyeon Jeong Lee, and Mau-Sun Chang (2011, Feb). hPuf-A/KIAA0020 Modulates PARP-1 Cleavage upon Genotoxic Stress. Cancer Research, 71(3):1126-34. (IF: 9.122; SCI, 15/217, ONCOLOGY).
  20. Po-Chen Chu, Tao-Yeuan Wang, Yen-Ta Lu, Chuan-Kai Chou, Yuh-Cheng Yang, Mau-Sun Chang (2009, Oct). Involvement of p29 in DNA damage responses and Fanconi anemia pathway. Carcinogenesis, 30(10):1710-1716. (IF: 5.105; SCI, 46/217, ONCOLOGY).
  21. Po-Chen Chu, Yuh-Cheng Yang, Yen-Ta Lu, Hsiang-Ting Chen, Lung-Chih Yu, and Mau-Sun Chang (2006, Sep). Silencing of p29 affects DNA damage responses with UV irradiation. Cancer Research, 66 (17):8484-8491. (IF: 9.122; SCI, 15/217, ONCOLOGY).
  22. Mau-Sun Chang, Yen-Ta Lu, Shin-Tsung Ho, Chao-Chih Wu, Tsai-Yin Wei, Chia-Ju Chen, Yun-Ting Hsu, Po-Chen Chu, Ching-Hsin Chen, Jien-Ming Chu, Ya-Lin Jan, Chia-Chien Hung, Chi-Chen Fan, Yuh-Cheng Yang (2004, Feb). Antibody detection of SARS-CoV spike and nucleocapsid protein. Biochemical and Biophysical Research Communications, 314 (4):931-936. (IF: 2.466; SCI, 163/286, BIOCHEMISTRY & MOLECULAR BIOLOGY).

Conference papers

  1. Hsing-Yu Wu, Ming-Chen Yang, Po-Chen Chu, Samuel K. Kulp, Ching-Shih Chen (2017, Apr). Novel function of p21-activated kinase 3 (PAK3) in regulating Akt phosphorylation and pancreatic cancer stem cell phenotypes.
  2. 2017 AACR, Walter E. Washington Convention Center, Washington, D.C., USA

  3. Po-Chen Chu, Ming-Chen Yang, Samuel K. Kulp and Ching-Shih Chen (2014, Apr). Targeting a Novel KRAS-Integrin-Linked Kinase Regulatory Circuitry in Pancreatic Cancer.
  4. 2014 AACR, San Diego Convention Center, San Diego, CA, USA.

    • Lisa Berman-Booty, Po-Chen Chu, Jennifer Thomas-Ahner, Dasheng Wang, Tiffany Yang, Steven Clinton, Samuel Kulp, Ching-Shih Chen (2012, Mar). Evaluation of the chemopreventive activity of the novel energy restriction mimetic agent OSU-CG5 in TRAMP mice.
    • OSUCCC-James 14th Annual Scientific Meeting, Ohio Union, Columbus, OH, USA.

    • Po-Chen Chu, Da-Sheng Wang, Samuel K. Kulp, Ching-Shih Chen (2012, Mar). Downregulation of IGF-1R expression by energy restriction-mimetic agents in prostate cancer through transcriptional and post-transcriptional regulation.
    • OSUCCC-James 14th Annual Scientific Meeting, Ohio Union, Columbus, OH, USA.

    • Po-Chen Chu, Tao-Yeuan Wang, Yen-Ta Lu, Chuan-Kai Chou, Yuh-Cheng Yang and Mau-Sun Chang (2009, Feb). A novel role of p29 in DNA damage checkpoint and Fanconi anemia pathway.
    • 2009 The Mammalian DNA Repair Gordon Research Conference, Four Points Sheraton, Ventura, CA, USA.

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