Faculty


NAME
    Chia-Lin Lee
TITLE
    Associate Professor
AFFILIATION
EDUCATION
    Ph.D., Graduate Institute of Natural Products, Kaohsiung Medical University
FIELDS OF
SPECIALTY
  • New Drug Development of Chinese Medicines
  • Natural Products Chemistry
RESEARCH INTERESTS
    Drug development of traditional Chinese medicine (TCM) for treatment and prevention of skin disorders
GRANTS
  • MOST 105-2320-B-039-047-MY3
  • MOST 103-2320-B-039-003-MY2
  • NSC 100-2113-M-039-003
Publications

Research papers

  1. I-Ting Weng, Yen-An Lin, Guan-Yu Chen, Hsiu-Mei Chiang, Yi-Jung Liu, Chao-Jung Chen, Yu-Hsuan Lan, Chia-Lin Lee*, (–)-β-Homoarginine anhydride, a new antioxidant and tyrosinase inhibitor, and further active components from Trichosanthes truncate. Nat. Prod. Res.   2018 Accepted
  2. Kuan-Ying Lai, Hao-Chun Hu, Hsiu-Mei Chiang, Yi-Jung Liu, Juan-Cheng Yang, Yen-An Lin, Chao-Jung Chen, Yuan-Shiun Chang, Chia-Lin Lee*, New diterpenes leojaponins G–L from Leonurus japonicas. Fitoterapia 2018, 130, 125−133.
  3. I-Hsiao Chen, Ming-Yi Yang, Shin-Hun Juang, Chia-Lin Lee, Tran-Dinh Thang, Mohamed EI-Shazly, Yu-Hsuan Lan* Bioactive components of Fissistigma cupreonitens. Nat. Prod. Commun. 2018, 13, 679−682.
  4. Chia-Lin Lee, Shou-Lun Lee, Chao-Jung Chen, Hsin-Chun Chen, Ming-Ching Kao, Chuan-Hao Liu, Jau-Yang Chen, Yen-Ting Lai, Yang-Chang Wu* Characterization of secondary metabolites from purple Ipomoea batatas leaves and their effects on glucose uptake. Molecules 2016, 21, 745; doi:10.3390/molecules21060745.
  5. Ching-Chia Li, Juan-Cheng Yang, Medi-Chin Lu, Chia-Lin Lee, Chieh-Yu Peng, Wei-Yu Hsu, Yun-Hao Dai, Fang-Rong Chang, Da-Yong Zhang, Wen-Jeng Wu,* Yang-Chang Wu* ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer. Oncotarget. 2016, 7, 1947−1959.
  6. Chieh-Yu Peng, Bang-Jau You, Chia-Lin Lee, Yang-Chang Wu, Wen-Hsin Lin, Te-Ling Lu, Fei-Ching Chang, Hong-Zin Lee* The roles of 4β-hydroxywithanolide E from Physalis peruviana on the Nrf2-antioxidant system and cell cycle in breast cancer cells. Am. J. Chin. Med. 2016, 44, 617−636.
  7. Ching-Peng Chiu, Shan-Chi Liu, Chih-Hsin Tang, You Chan, Mohamed EI-Shazly, Chia-Lin Lee, Ying-Chi Du, Tung-Ying Wu, Fang-Rong Chang,* Yang-Chang Wu* Anti-inflammatory cerebrosides from cultivated Cordyceps militaris. J. Agric. Food Chem. 2016, 64, 1540−1548.
  8. Chia-Lin Lee, Tsong-Long Hwang, Chieh-Yu Peng, Chao-Jung Chen, Chao-Lin Kou, Wen-Yi Chang, Yang-Chang Wu* Anti-inflammatory and cytotoxic compounds from  Solanum macaonense. Nat. Prod. Commun. 2015, 10, 345−348.
  9. Chia-Lin Lee,* Ming-Hon Yen, Tsong-Long Hwang, Juan-Cheng Yang, Chieh-Yu Peng, Chao-Jung Chen, Wen-Yi Chang, Yang-Chang Wu Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia. Phyto. Lett. 2015, 12, 237−242.
  10. Chieh-Yu Liao, Chia-Lin Lee, Hui-Chun Wang, Shih-Shin Liang, Po-Hsiung Kung, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung Wu* CLL2-1, a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-1 (CalDAG-GEFI). Free Radic. Bio. Med. 2015, 78, 101−110.
  11. Jung-Chun Liao, Kun-Tsung Lee, Bang-Jau You, Chia-Lin Lee, Wen-Te Chang, Yang-Chang Wu, Hong-Zin Lee* Raf/ERK/Nrf2 signaling pathway and MMP-7 expression involvement in the trigonelline-mediated inhibition of hepatocarcinoma cell migration. Food Nutr. Res. 2015, 59, 29884.

Conference papers

  1. Anti-melanogenesis and antioxidant components from Ampelopsis japonica, The 33th Symposium on Natural Products, Kaohsiung/Taiwan, 2018.10.06-2018.10.07
  2. New indole alkaloids from Qing Dai, , The 33th Symposium on Natural Products, Kaohsiung/Taiwan, 2018.10.06-2018.10.07
  3. Secondary metabolites isolated from Pharbitis nil, The 33th Symposium on Natural Products, Kaohsiung/Taiwan, 2018.10.06-2018.10.07
  4. Anti-melanogenesis LJMEH from Leonurus japonicus, The 33th Symposium on Natural Products, Kaohsiung/Taiwan, 2018.10.06-2018.10.07
  5. Anti-metastatic and anti-allergic spirostanol saponins from Solanum macaonense and S. torvum, 65th Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Basel/Switzerland, 2017.9.3-2017.9.7
  6. Anti-melanogenesis components from Leonurus japonicas, 65th Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Basel/Switzerland, 2017.9.3-2017.9.7
  7. The components isolated from active LJMWB crude fraction of Leonurus japonicas, The 32th Symposium on Natural Products, Taichung/Taiwan, 2017.10.13- 2017.10.14
  8. Chemical profile analysis and active components from the root of Cynara scolymus. The 29th Symposium on Natural Products, Taichung/Taiwan, 2017.10.13- 2017.10.14
  9. Anti-melanogenesis components from traditional Chinese medicine, Pharbitidis Semen, The 9th China Medical University and Asia University Joint Conference on Biotechnology, Taichung/Taiwan, 2016.3.14 -2016.3.14
  10. Developing anti-melanogenesis agents from a traditional Chinese medicine, Leonurus japonicas, The 31th Symposium on Natural Products & Symposium of Pharmacy and Traditional Chinese Medicine, Kaohsiung/Taiwan, 2016.10.14- 2016.10.15
  11. Anti-glucose uptake secondary metabolites from purple Ipomoea batatas leaves, The 31th Symposium on Natural Products & Symposium of Pharmacy and Traditional Chinese Medicine, Kaohsiung/Taiwan, 2016.10.14 ~ 2016.10.15
  12. Antineutrophilic inflammatory secondary metabolites from Solanum macaonense, 63rd GA, Budapest/Hungary, 2015.8.23- 2015.8.27
  13. Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia, The 29th Symposium on Natural Products, Kaohsiung/Taiwan, 2014.9.27-2014.9.28
  14. Bioactive steroidal glycosides from Solanum torvum, 2012 International Congress on Natural Products Research, New York/USA, 2012.7.28-2012.8.1
  15. Anti-neutrophilic inflammatory secondary metabolites from traditional Chinese medicine, Tiankuizi, The 27rd Symposium on Natural Products, Kaohsiung/Taiwan, 2012.10.6-2012.10.7
  16. Cytotoxic and antiplatelet aggregation metabolites from Calanthe arisanensis, 52nd Annual Meeting of the American Society of Pharmacognosy, San Diego/USA, 2011.7.30-2011.8.3

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