Yu-Hsuan Lee

Full-Time Faculty

 
NAME

Yu-Hsuan Lee

TITLE

Assistant professor
AFFILIATION

Tel: +886-4-22053366 ext 6509

E-mail: yhlee@mail.cmu.edu.tw
EDUCATION

Ph.D., Department of Environmental and Occupational Health, National Cheng Kung University
FIELDS OF
SPECIALTY
  1. Toxicology
  2. Cell Biology
  3. Skin immunology
  4. Nanomedcine / Nanotoxicology
  5. Nature products prevent allergic contact dermatitis and skin aging
RESEARCH INTERESTS
  1. The safety of nanoparticles and nature product via the formulation procedure to enhance its chemopreventive potency
  2. Discovery of biomarker related to health physiological conditions and lifespan.

HONORS
  • Excellent Research Award, College of Medicine, National Cheng Kung University, Tainan, Taiwan. 29 Jun, 2014.
  • Excellent Research Award, College of Medicine, National Cheng Kung University, Tainan, Taiwan. 1 Jun, 2015.
  • Travel Award, EMBO conference-Structure and function of the endoplasmic reticulum, Girona, Spain. 23-27 Oct, 2016.
  • Innovative BioDesign Award, National Cheng Kung University, Tainan, Taiwan. 28 Jun, 2017
  • Second place in Startup Competition, National Cheng Kung University, Tainan, Taiwan. 6 Jan, 2018
  • Best Poster Award. The 34th Joint of Annual Conference of Biomedical Science, Taipei, Taiwan. 23-24 Mar, 2019.
  • Preparatory. Taiwan-Korea Conference for Environmental and Occupational Health. 17 Feb, 2017
  • Executive Secretary. 1st winter camp congress of the Taiwan Society of Toxicology. 26-28 Jan, 2019.
PUBLICATIONS

Research papers

  1. Y-H Hsu#, H-C Chuang, Y-H Lee, Y-F Lin, Y-J Chen, T-C Hsiao, M-Y Wu# and H-W Chiu*. Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo. Free Radical Biology & Medicine. 135: 235-244 (2019) (S.C.I. Impact factor: 6.020. Subject Category: 17/142=12% in Endocrinology & Metabolism, JCR 2017)   
  2. B-J Wang, H-W Chiu, Y-Lin Lee, C-Yi Li, Y-J Wang and Y-H Lee. Pterostilbene attenuates hexavalent chromium-induced allergic contact dermatitis by preventing cell apoptosis and inhibiting IL-1β-related NLRP3 inflammasome activation. Journal of Clinical Medicine 7(12), 489 (2018) (S.C.I. Impact factor: 5.583. Subject Category: 15/154=9.7% in Medicine, General & Internal, JCR 2017) (Corresponding author) MOST 107-2314-B-006-007
  3. R-J Chen, H-C Kuo, L-H Cheng, Y-H Lee, W-T Chang, B-J Wang, Y-J Wang and H-C Cheng. Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer. Int J Mol Sci. 19(1), 287 (2018). (S.C.I. Impact factor: 3.687. Subject Category: 52/170=30.5% in Chemistry, Multidisciplinary, JCR 2017)
  4. Y-F Lin, Y-H Lee, Y-H Hsu, Y-J Chen, Y-F Lin, F-Y Cheng and H-W Chiu. Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease. Nanomedicine 12(22):2741-2756 (2017) (S.C.I. Impact factor: 5.005. Subject Category: 22/159=13.8% in Biotechnology & Applied Microbiology, JCR 2017)
  5. Y-H Lee, C-Y Fang, H-W Chiu, F-Y Cheng, J-C Tsai, C-W Chen and Y-J Wang. Endoplasmic reticulum stress-triggered autophagy and lysosomal dysfunction contribute to the cytotoxicity of amine-modified silver nanoparticles in NIH 3T3 cells. J. Biomed. Nanotech. 13: 778–794 (2017) (S.C.I. Impact factor: 5.068. Subject Category: 7/33 =21.2% in Materials Science, Biomaterials, JCR 2017) (First author).
  6. R-J Chen, Y-H Lee, Y-L Yeh, W-S Wu, C-T Ho, C-Y Li, Y-J Wang and B-J Wang. Autophagy-inducing Effect of Pterostilbene: a Prospective Therapeutic/Preventive Option for Skin Diseases. J Food Drug Anal. 25:125-133 (2017) (S.C.I. Impact factor: 2.852. Subject Category: 33/133=24.8% in Food Science and Technology, JCR 2017) (co-First author)
  7. R-J Chen, Y-H Lee, Y-L Yeh, Y-J Wang and B-J Wang. The Roles of Autophagy and the Inflammasome during Environmental Stress-Triggered Skin Inflammation. Int J Mol Sci. 17(12):2063 (2016). (S.C.I. Impact factor: 3.687. Subject Category: 52/170=30.5% in Chemistry, Multidisciplinary, JCR 2017) (co-First author)
  8. Y-F Lin, I-J Chiu, F-Y Cheng, Y-H Lee, Y-J Wang, Y-H Hsu and H-W Chiu. The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo. Particle and Fibre Toxicology. 13:52 (2016). (S.C.I. Impact factor: 6.105. Subject Category: 5/94=5.3% in Toxicology, JCR 2017) 
  9. H-M Chen, Y-H Lee, Y-J Wang. ROS-Triggered Signaling Pathways Involved in the Cytotoxicity and Tumor Promotion Effects of Pentachlorophenol and Tetrachlorohydroquinone. Chem Res Toxicol. 28(3):339-50 (2015). (S.C.I. Impact factor: 3.432 Subject Category: 21/94 =22.3% in Toxicology, JCR 2017) (co-First author)
  10. H-W Chiu, T Xia, Y-H Lee, C-W Chen, J-C Tsai, and Y-J Wang *. Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress. Nanoscale. 7(2):736-462 (2015)(S.C.I. Impact factor: 7.233. Subject Category: 30/283 =10.6% in Materials science, multidisciplinary, JCR 2017)
  11. Y-H Lee, F-Y Cheng, H-W Chiu, J-C Tsai, C-Y Fang, C-W Chen and Y-J Wang. Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts. Biomaterials 35: 4706-4715 (2014) (S.C.I. Impact factor: 8.806. Subject Category: 1/77 =1.3% in Engineering, biomedical, JCR 2017) NSC 102-2314-B-006-034 (First author)
  12. J-W Guo, Y-H Lee, H-W Huang, M-C Tzou, Y-J Wang, J-C Tsai. Development of Taiwan’s strategies for regulating nanotechnology-based pharmaceuticals harmonized with international considerations. Int. J. Nanomedicine 9:4773-4783 (2014) (S.C.I. Impact factor: 4.37. Subject Category: 31/261 =11.8% in Pharmacology & pharmacy, JCR 2017)
  13. Y-H Lee, S-B Su, C-C Huang, H-M Sheu, J-C Tsai, C-H Lin, Y-J Wang, B-J Wang. N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression. PLoS ONE. 9: e108317 (2014) (S.C.I. Impact factor: 2.766. Subject Category: 15/64 =23.4% in Multidisciplinary sciences, JCR 2017) NSC-102-2314-B-006-034 (First author)
  14. H-M Chen, Y-H Lee, R-J Chen, H-W Chiu, B-J Wang and Y-J Wang. The immunotoxic effects of dual exposure to PCP and TCDD. Chem-Biol Interact. 206:166-174 (2013) (S.C.I. Impact factor: 3.296. Subject Category: 24/94=25.5% in Toxicology, JCR 2017) NSC 101-2314-B-006-050 (co-First author)
  15. N-P Foo, S-H Lin, Y-H Lee, M-J Wu, Y-J Wang*. α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β. Toxicology 282: 39-46 (2011) (S.C.I. Impact factor: 3.265. Subject Category: 26/94=27.6% in Toxicology, JCR 2017) NSC 98-2314-B-006-034-MY2
  16. B-J Wang, H-M Sheu, Y-Lg Guo, Y-H Lee, C-S Lai, M-H Pan, Y- J Wang*. Hexavalent chromium-induced ROS formation, Akt, NF-κB, and MAPK activation, and TNF-α and IL-1α production in keratinocytes. Toxicol. Lett. 198: 216-224 (2010) (S.C.I. Impact factor: 3.166. Subject Category: 29/94=30.8% in Toxicology, JCR 2017) NSC 98-2314-B-006-034-MY2
  17. B-J Wang, Y-L Guo, H-Y Chang, H-M Sheu, M-H Pan, Y-H Lee and Y-J Wang*. N-acetylcysteine inhibits chromium hypersensitivity in coadjuvant chromium-sensitized albino guinea pigs by suppressing the effects of reactive oxygen species. Exp. dermatol. 19: e191-e200 (2010) (S.C.I. Impact factor: 2.608. Subject Category: 19/63 =30.1% in Dermatology, JCR 2017) NSC-95-2314-B-006-095-MY3.