You-Cheng Hseu

Full-Time Faculty

 
NAME

You-Cheng Hseu
TITLE

Professor
AFFILIATION

Tel: +886-4-22053366 ext 5308

E-mail: ychseu@mail.cmu.edu.tw

Website: http://mail.cmu.edu.tw/~ychseu/
EDUCATION

TAIPEI Medical University, TAIWAN (台北醫學大學保健營養學士, B.S)

National TSIN-HUA University, TAIWAN (國立清華大學生命科學博士, PhD)

MD ADERSON CANCER CENTER, USA (美國德州大學MD Anderson 癌症中心訪問學者, Visiting Scientist)
FIELDS OF
SPECIALTY
  1. Free Radical Biology and Medicine
  2. Bioactivities of the Traditional Chinese Medicine
  3. Antioxidants and Cosmeceutics
RESEARCH INTERESTS

I am a Professor at the China Medical University. My primary research interest is Nutritional Biochemistry and Toxicology; Bioactivities of Natural Products and Traditional Chinese Herbal Medicine; Free Radical Biology and Medicine; Antrodia camphorata and their Bioactive Constituents for Breast Cancer Chemoprevention; Antioxidants, Anti-aging, Anti-inflammation, Wound healing, and Herbal Cosmeceutics; UVA-Induced Skin Damage and Skin Cancer Chemoprevention.
GRANTS Positions and Honors
  1. 2018 Project sanction committee member (Optimize the environment of Technical colleges), Ministry of Education, Taiwan, ROC. (教育部優化技職環境計畫初審/複審審查委員)
  2. Project sanction committee member (Technical colleges), Ministry of Education, Taiwan, ROC. (教育部技職再造計畫初審/複審審查委員)
  3. Project sanction committee member (Equipment Update of Technical colleges), Ministry of Education, Taiwan, ROC. (教育部第二期技職再造計畫技專院校設備更新初審/複審審查委員)
  4. Project sanction committee member (International Symposium in Taiwan), National Science Council, Taiwan, ROC. (國科會補助國內舉辦國際學術研討會審查委員)
  5. Project sanction committee member, National Science Council, Taiwan, ROC. (國科會研究計畫初審/複審審委員)
  6. Project sanction committee member (Technical colleges, Department of degree renamed/merged), Ministry of Education, Taiwan, ROC. (教育部技專校-院所系科學位學程改名整併案審查委員)
  7. Project sanction committee member (Postgraduate degree), Ministry of Education, Taiwan, ROC. (教育部學士後學位學程審查委員)
  8. Committee member (Technical colleges), Taiwan Assessment and Evaluation and Association, ROC. (台灣評鑑協會科技大學訪視評鑑委員)
  9. Project sanction committee member, MOST Germination Program, Taiwan, ROC. (科技部萌芽計畫審查委員)
  10. Project sanction committee member (Master newly established), Ministry of Education, Taiwan, ROC. (教育部碩士班新設審查委員)
  11. Committee member (Industry-Academic Cooperation Plan of Technical Colleges), Chinese Management Association, ROC. (中華民國管理科學學會-技專校院產學攜手合作計畫評鑑委員)
  12. Committee member (Rename and Reconstruction of Technical Colleges), Taiwan Assessment and Evaluation and Association, ROC. (台灣評鑑協會技專校院改名改制委員會評鑑委員)
  13. Project sanction committee member (The establishment of special adjustment institutions of Technical Colleges), Taiwan Assessment and Evaluation and Association, ROC. (台灣評鑑協會大學校院增設調整特殊項目院系所學位學程評鑑委員)
  14. Proposition committee, Ministry of Examination, Taiwan. ROC.(考選部專技高考命題委員)
  15. Project sanction committee member, Council of Agriculture and Executive Yuan, Taiwan. ROC. (農委會研究計畫審查委員)
  16. Project sanction committee member (College student research program), National Science Council, Taiwan. ROC. (國家科學委員會大專生研究計畫審查委員)

Honors and Academic service:

  1. 2018 Best paper award, Chinese Society of Cosmetic Surgery and Anti-aging Medicine, Taiwan. (2018中華民國美容醫學會 優秀論文獎第三名)
  2. 2007-2018 The Excellent Research Reward of University, Ministry of Science and Technology, Taiwan. (科技部大專校院特殊優秀人才獎勵)
  3. 2016 Best paper award, Chinese Society of Cosmetic Surgery and Anti-aging Medicine, Taiwan. (中華民國美容醫學會 優秀論文獎第二名)
  4. 2012 Dr. Hong-Yen Hsu Academic Award of Chinese Medicine, Taiwan. (許鴻源中醫藥研究獎)
  5. 2007-2010, 2010-2013, 2013-2017 The Outstanding Research Award, China Medical University, Taiwan. (中國醫藥大學傑出研究獎勵)
  6. 2007 The Second Outstanding Research Award, college of Pharmacolgy, China Medical University, Taiwan.(中國醫藥大學96學年度藥學院傑出研究績優獎第二名)
  7. 2007 International Health Professional of the Year (International Biographical Center, Cambridge, England). (英國劍橋名人自傳-國際健康年度教授)
  8. 2006 The first Outstanding Research Award, college of Pharmacolgy, China Medical University, Taiwan. (中國醫藥大學95學年度藥學院傑出研究績優獎第一名)
  9. 2006-2007 Marquis Who's Who in Medicine and Healthcare. (世界名人錄/亞洲名人錄/醫學與健康照護名人錄)
  10. 2001 The Second Best Annual paper, Mid-Taiwan Journal of Medicine. (中台灣醫學科學雜誌年度優良論文第二名)
  11. 1996 The Third Best paper award, Biophysics Conference, Taiwan. (生物物理研討會論文第三名)
  12. 1995 Dr. Hsu Chien-Tien Award, Taiwan. (徐千田研究生論文獎)
  13. 1995 Best paper award, Molecular Biology Conference, Taiwan. (生物醫學研討會賽研究生優秀論文獎)

Associate Editor

  • Journal of Toxicology

Reviewer

  • Cancer research, Biochemical Pharmacology, Pharmacological Research, Journal of Investigative Dermatology, Cancer Prevention Research, Current Organic Chemistry,Evidence-based Complementary and Alternative Medicine, ISRN toxicology, International Journal of Molecular Sciences, Molecules, Nitric Oxide, Journal of Agricultural and Food Chemistry, Phytomedicine, Life Science, Journal of Ethanopharmacology, Food Chemical and Toxicology, Environmental Toxicology, Journal of Food and Drug Analysis, Journal of Chinese medicine.

Editorial Board Member

  • Austin Leukemia, Annals of Nutrition and Food Science, SciTz Gynecology & Reproductive Medicine, Clinical oncology, Journal of Food and Nutrition, European Journal of Toxicological Sciences, International Scholarly Research Notices, Asian Journal of Pharmacological Sciences, American Journal of Food and Nutrition, Austin Anaplastology, Journal of Cancer and Cure, Journal of Surgical Dermatology, American Journal of Leukemia Research, SRL Biology journal, SM Journal of Bioprocessing & Biotechniques, Journal of Clinical Trials in Oncology.

 
PUBLICATIONS
  1. You-Cheng Hseu, M Korivi, FY Lin, ML Li, RW Lin, JJ Wu, HL Yang. Trans-cinnamic acid attenuates UVA-induced photoaging through inhibition of AP-1 activation and induction of Nrf2-mediated antioxidant genes in human skin fibroblasts. Journal of Dermatological Science, (2018) Accepted. (7/63, Dermatology: IF=3.733)
  2. HL Yang, CL Lee, M Korivi, P Rajendran, JW Liao, JJ Wu, You-Cheng Hseu*. Zerumbone Protects Human Skin Keratinocytes against UVA-irradiated Damages through Nrf2 Induction. Biochemical Pharmacology, (2018) Accepted. (18/255, PHARMACOLOGY & PHARMACY: IF=5.091)
  3. You-Cheng HseuV Thiyagarajan, TT Ou*, HL Yang. CoQ0 induced mitochondrial PTP opening to trigger apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice. Archives of Toxicology. (2017) Accepted. doi: 10.1007/s00204-017-2050-6 (5/90, Toxicology: IF=6.637)
  4. You-Cheng Hseu, TJ Tsai, M Korivi, JY Liu, HJ Chen, CM Lin, YC Shen, HL Yang. Antitumor properties of Coenzyme Q0 against human ovarian carcinoma cells viainduction of ROS-mediated apoptosis and cytoprotective autophagy.Scientific Reports (2017) 7(1):8062 (7/63, MULTIDISCIPLINARY SCIENCES, IF=5.228)
  5. CT Chang, You-Cheng Hseu*, V Thiyagarajan, KY Lin, TD Way, M Korivi, JW Liao, HL Yang. Chalcone Flavokawain B Induces Reactive Oxygen Species-Mediated Autophagy in Human Gastric Carcinoma and Suppresses Tumor Growth in Mice. Archives of Toxicology. (2017) 91(10), 3341-3364. (5/90, Toxicology: IF=6.637)
  6. HL Yang, M Korivi, CH Chen, WJ Peng, CS Chen, ML Li, LS Hsu, JW Liao, You-Cheng Hseu*. Antrodia camphorata Attenuates Cigarette Smoke-induced ROS Production, DNA Damage, Apoptosis and Inflammation in Vascular Smooth Muscle Cells, and Atherosclerosis in ApoE-deficient Mice. Environmental Toxicology. (2017) Accepted. (7/85, WATER RESOURCES: IF=2.868)
  7. You-Cheng Hseu, TW Hsu, HD Lin, CH Chen, SC Chen. Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food and Chemical Toxicology. (2017) 103: 253-260 (13/125, FOOD SCIENCE & TECHNOLOGY: IF=3.584)
  8. CT Chang, You-Cheng Hseu (Co-first author), HC Huang, V Thiyagarajan, KY Lin, PJ Huang, JY Liu, M Korivi and HL Yang*. Inhibition of ROS production, autophagy or apoptosis signaling reversed anticancer properties of Antrodia salmonea in triple-negative breast cancer (MDA-MB-231) cells. Food and Chemical Toxicology. (2017) 103, p1-17 (13/125, FOOD SCIENCE & TECHNOLOGY: IF=3.584)
  9. 9. CT Chang, You-Cheng Hseu (Co-first author), V Thiyagarajan, HC Huang, LS Hsu, PJ Huang, JY Liu, JW Liao, HL Yang*. Antrodia salmonea induces G2 cell-cycle arrest in human triple-negative breast cancer (MDA-MB-231) cells and suppresses tumor growth in athymic nude mice. Journal of Ethanopharmacology. (2017) 208:72-83. (2/24, INTEGRATIVE & COMPLEMENTARY MEDICINE Ranking: IF=3.055).
  10. You-Cheng Hseu, YH Chao, KY Lin, TD Way, HY Lin, V Thiyagarajan, HL Yang. Antrodia campharata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells. Journal of Ethanopharmacology. (2017) (2/24, INTEGRATIVE & COMPLEMENTARY MEDICINE Ranking: IF=3.055).
  11. Sun DP, Fang CL, Chen HK, Wen KS, You-Cheng Hseu, Hung SH, Uen YH, Lin KY. EPAC1 overexpression is a prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer. Oncology Reports. (2017) 37(4):1953-1960. (Impact factor: 2.486, Ranking 61.0%)
  12. HL Yang, YC Tsai, M Korivi, CT Chang, You-Cheng Hseu*. Lucidone Promotes Cutaneous Wound Healing Process via Activation of PI3K/AKT, Wnt/β-catenin and NF-κB Signaling Pathways. BBA-Molecular Cell Research. (2017) 1864, 151-168 (50/289, BIOCHEMISTRY & MOLECULAR BIOLOGY: IF=5.128)
  13. HL Yang, M Korivi, MK Lin, Hebron CW Chang, CR Wu, MS Lee, William TL Chen and You-Cheng Hseu*. Anti-hemolytic and Antioxidant Properties of Pearl Powder against AAPH-induced Hemolysis and Oxidative Damage to Erythrocytes Membrane Lipids and Proteins. Journal of food and drug analysis. (2017) 25(4):898-907 (39/125, FOOD SCIENCE & TECHNOLOGY: IF=3.048).
  14. CC Lin, CL Fang, DP Sun, You-Cheng Hseu, YH Uen, KY Lin, YC Lin. High expression of mitochondrial intermembrane chaperone TIMM9 represents a negative prognostic marker in gastric cancer. Journal of the Formosan Medical Association. (2016). 116(6):476-483 (46/155, JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, IF: 2.018)
  15. HM Wang, HL Yang, V Thiyagarajan, TH Huang, PJe Huang, SC Chen, JY Liu, LS Hsu, HW Chang, and You-Cheng Hseu*. Coenzyme Q0 enhances ultraviolet B-induced apoptosis in human estrogen receptor-positive breast (MCF-7) cancer cells (2016). Intergative Cancer Therapies. 1–12 DOI：10.1177/1534735416673907 (8/24, INTEGRATIVE & COMPLEMENTARY MEDICINE: IF=1.706)
  16. HC Chen, WT Chang, You-Cheng Hseu, HY Chen, CH Chuang, CC Lin, MS Lee, MK Lin . Immunosuppressive effect of Litsea cubeba L. essential oil on dendritic cell and contact hypersensitivity responses. International Journal of Molecular Sciences, (2016) 17(8), 1319. (IF: 3.257; Ranks: Chemistry, Multidisciplinary, 52/163)
  17. You-Cheng Hseu, V Thiyagaraja, HT Tsou, KY Lin, HJ Chen, CM Lin, JW Liao, HL Yang. In vitro and in vivo anti-tumor activity of CoQ0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis through modulation of Wnt/β-catenin signaling pathways. Oncotarget. (2016) (7) 22409-22462 (36/213, Oncology: IF=5.008)
  18. HY Chou, C Lee, JL Pan, ZH Wen, SH Huang, CW John Lan, WT Liu, TC Hour, You-Cheng Hseu, BH Hwang, KC Cheng, HM David Wang. Enriched Astaxanthin Extract from Haematococcuspluvialis Augments Growth Factor Secretions to Increase Cell Proliferation and Induces MMP1 Degradation to Enhance Collagen Production in Human Dermal Fibroblasts. International Journal of Molecular Sciences, (2016) 17(6), 955-967. (IF: 3.257; Ranks: Chemistry, Multidisciplinary, 52/163)
  19. HL Yang, V Thiyagarajan, JW Liao, YL Chu, CT Chang, PJ Huang, CJ Hsu, You-Cheng Hseu*. Toona sinensis inhibited murine leukemia WEHI-3 cells and promoted immune response in vivo. Intergative Cancer Therapies. (2016) DOI: 10.1177/1534735416673907 (8/24, INTEGRATIVE & COMPLEMENTARY MEDICINE: IF=1.706)
  20. HL Yang, MW Lin, M Korivi, JJ Wu, CH Liao, CT Chang, JW Liao, You-Cheng Hseu* . Coenzyme Q0 Regulates NFκB/AP-1 Activation and Enhances Nrf2 Stabilization in Attenuation of LPS-induced Inflammation and Redox Imbalance: Evidence From In Vitro and In Vivo Studies. BBA-Gene Regulatory Mechanisms. (2016) 1859, 246-261 (42/289, BIOCHEMISTRY & MOLECULAR BIOLOGY: IF=5.373)
  21. H.C. Chang, HL Yang, JH Pan, M Korivi, JY Pan, MC Hsieh, PM Chao, PJ Huang, CT Tsai, You-Cheng Hseu*. Hericium erinaceus inhibits TNF-α-induced angiogenesis through suppression of MMP-9 and modulation of NF-κB/Nrf2 signaling pathways in human endothelial cells. Oxidative Medicine and Cellular Longevity. (2016) ID 8257238 (53/187, CELL BIOLOGY : IF=4.492)
  22. You-Cheng Hseu, KC Cheng, YC Lin, CY Chen, HY Chou, DL Ma, CH Leung, ZH Wen, HMD Wang. Synergistic effects of linderanolide B combined with arbutin, PTU or kojic acid on tyrosinase inhibition. Current Pharmaceutical Biotechnology (2015) 16(12):1120-6 (112/254, PHARMACOLOGY & PHARMACY: IF=2.5)
  23. HL Yang, M Korivi, MW Lin, SC Chen, CW Chou, You-Cheng Hseu*. Anti-angiogenic Properties of Coenzyme Q0 through Downregulation of MMP-9/NF-κB and Upregulation of HO-1 Signaling in TNF-α-activated Human Endothelial Cells. Biochemical Pharmacology (2015) 98, 144-152 (18/255, PHARMACOLOGY & PHARMACY: IF=5.091)
  24. You-Cheng Hseu, YC Huang, M Korivi, JJ Wu, TD Way, TT Ou, LW Chiu, CC Lee, ML Lin, HL Yang. Zerumbone attenuates TGF-β1-mediated epithelial-mesenchymal transition via upregulated E-cadherin expression and downregulated Smad2 signaling pathways in non-small cell lung cancer (A549) cells. Journal of Functional Foods (2015) 303-318. (8/125, FOOD SCIENCE & TECHNOLOGY: IF=3.973)
  25. You-Cheng Hseu, HW LO, M Korivi, YC Tsai, MJ Tang, HL Yang* (2015) Dermato-protective Properties of Ergothioneine through Induction of Nrf2/ARE-mediated Antioxidant Genes in UVA-irradiated Human Keratinocytes. Free Radical Biology and Medicine, 82, 102-117 (14/133, ENDOCRINOLOGY & METABOLISM, IF=5.784)
  26. YH Uen, CL Fang, You-Cheng Hseu, PC Shen, HL Yang, KS Wen, ST Hung, LH Wang, KY Lin. (2015) VAV3 Oncogene Expression in Colorectal Cancer: Clinical Aspects and Functional Characterization. Scientific Reports, 20;5:9360 (7/63, MULTIDISCIPLINARY SCIENCES, IF=5.228)
  27. HL Yang, SW Lin, CC Lee, KY Lin, CH Liao, TY Yang, HM Wang, HC Huang, CR Wu, You-Cheng Hseu*. (2015) Induction of Nrf2-mediated genes by Antrodia salmonea inhibits ROS generation and inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages. Food and Function. 24, 229-240 (25/125, FOOD SCIENCE & TECHNOLOGY: IF=2.686).
  28. You-Cheng Hseu, YC Tsai, PJ Huang, TT Ou, M Korivi, LS Hsu, SH Chang, CR Wu, HL Yang. (2015) The dermato-protective effects of lucidone from Lindera erythrocarpa through the induction of Nrf2-mediated antioxidant genes in UVA-irradiated human skin keratinocytes. Journal of Functional Foods, 2015, 303-318. (8/125, FOOD SCIENCE & TECHNOLOGY: IF=3.973)
  29. MHC Chen, LC Hsu, JL Wu, CW Yeh, JN Tsai, You-Cheng Hseu, LS Hsu. Exposure to benzidine caused apoptosis and malformation of telencephalon region in zebrafish. Environmental Toxicology. (2014) 24, 1428-1436. (7/85, WATER RESOURCES: IF=2.868)
  30. Lin VC, Kuo PT, Lin YC, Chen Y, You-Cheng Hseu, Yang HL, Kao JY, Ho CT, Way TD. Penta-O-galloyl-β-d-glucose Suppresses EGF-Induced eIF3i Expression through Inhibition of the PI3K/AKT/mTOR Pathway in Prostate Cancer Cells. (2014) Journal of Agricultural and Food Chemistry 2014, 62 (36), pp 8990–8996. (3/57, AGRICULTURE, MULTIDISCIPLINARY : IF=2.857)
  31. HL Yang, PJ Huang, SC Chen, HJ Cho, K.J.S Kumar, FJ Lu, CS Chen, CT Chang, You-Cheng Hseu. Induction of Macrophage Cell-Cycle Arrest and Apoptosis by Humic Acid. Environmental and Molecular Mutagenesis. (2014), 55; 741-750 (46/225, ENVIRONMENTAL SCIENCES: IF=3.326).
  32. HL Yang, KJS Kumar, YT Kuo, HC Chang, JW Liao, LS Hsu, You-Cheng Hseu*. Antrodia camphorata induces G1 cell-cycle arrest in human premyelocytic leukemia (HL-60) cells and suppresses tumor growth in athymic nude mice. Food and Function. (2014) 5, 2278-2288 (25/125, FOOD SCIENCE & TECHNOLOGY: IF=2.686).
  33. You-Cheng Hseu, CC Lee, YC Chen, K.J.S. Kumar, CS Chen, YC Huang, LS Hsu, HC Huang, HL Yang. The anti-tumor activity of Antrodia salmonea in human promyelocytic leukemia (HL-60) cells is mediated via the induction of G1 cell-cycle arrest and apoptosis in vitro or in vivo. Journal of Ethanopharmacology. (2014) 53 (2), 499-510. (2/24, INTEGRATIVE & COMPLEMENTARY MEDICINE Ranking: IF=3.055).
  34. ACH Liao, CC Kuo, YC Huang, CW Yeh, You-Cheng Hseu, JY Liu, LS Hsu. Naringenin inhibited migration of bladder cancer cells via downregulation of AKT and MMP-2. (2014). Accepted. Molecular Medicine Reports. (85/124, MEDICINE, RESEARCH & EXPERIMENTAL : IF=1.559).
  35. MJ Lee, SH Kao, JE Hunag, GT Sheu, CW Yeh, You-Cheng Hseu, CJ Wang, LS Hsu. Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species. (2014) Chemico-Biological Interactions. 211, 44-53. (98/255, PHARMACOLOGY & PHARMACY: IF=2.618)
  36. HL Yang, PJ Huang, Yu Liu, K.J.S. Kumar, LS Hsu, TL Lu, YC Chia, Tokuko Takajo, Anzai Kazunori, You-Cheng Hseu*. Toona sinensis Inhibits LPS-Induced Inflammation and Migration in Vascular Smooth Muscle Cells via Suppression of Reactive Oxygen Species (ROS) and NF-κB Signaling Pathway. Oxidative Medicine and Cellular Longevity. (2014) (2014: 901315) (53/187, CELL BIOLOGY : IF=4.492)
  37. You-Cheng Hseu, CC Lee, CY Chang, KJS Kumar, CS Chen, HC Huang, HL Yang. Antioxidant activities of Antrodia salmonea in submerged culture using in vitro antioxidant models and protecting human erythrocytes and low density lipoproteins against oxidative modification. Food and Chemical Toxicology. (2014) 66, 150-157. (13/125, FOOD SCIENCE & TECHNOLOGY: IF=3.584).
  38. LC Chen, JC Wu, YF Tuan, YK Tseng, You-Cheng Hseu, SC Chen. Molecular mechanisms of 3,3’-dichlorobenzidine-mediated toxicity in HepG2 cells. Environmental and Molecular Mutagenesis. (2014), DOI: 10.1002/em.21858. (46/225, ENVIRONMENTAL SCIENCES : IF=3.326).
  39. You-Cheng Hseu, KJS Kumar, CS Chen, HJ Cho, SW Lin, PC Shen, CW Lin, FJ Lu, HL Yang. The Inflammatory Potential of Humic Acid in Drinking Well Water: A Possible Role in Atherosclerosis. Toxicology and applied Pharmacology (2014), 274, 249-262. (12/90, TOXICOLOGY : IF=3.847)
  40. HL Yang, HC Chang, SW Lin, KJS Kumar, CH Liao, HM Wang, KY Lin, You-Cheng Hseu*. Antrodia salmonea inhibits TNF-α-induced angiogenesis and atherogenesis in human endothelial cells through the down-regulation of NF-κB and up-regulation of Nrf2 signaling pathways. Journal of Ethanopharmacology. 2014, 151, 394-406. (2/24, INTEGRATIVE & COMPLEMENTARY MEDICINE Ranking: IF=3.055).