Po-Chen Chu

Full-Time Faculty

 
NAME

Po-Chen Chu
TITLE

Assistant professor
AFFILIATION

Tel: +886-4-22053366 ext 5312

E-mail:tyjuang@mail.cmu.edu.tw
EDUCATION

Ph.D., Institute of Biochemical Sciences National Taiwan University, Taipei, Taiwan
FIELDS OF
SPECIALTY
  1. Molecular Biology
  2. Cell Biology
  3. Cancer Biology
  4. Signal transduction
RESEARCH INTERESTS
  1. Cancer metastasis
  2. The role of microRNAs in cancer growth and metastasis
  3. Hsp70 inhibitor
GRANTS

Title: Targeting PAK3 to eradicate pancreatic cancer stem cells by suppressing Wnt/beta-catenin signaling

Title: Study the role of oncogenic KRAS/miR-137 signaling axis in colorectal cancer liver metastasis

Title: Targeting HDAC 8 to eradicate breast cancer stem cells by suppressing Notch1 signaling

Title: Targeting a Novel KRAS-Integrin-Linked Kinase Regulatory Circuitry in Pancreatic Cancer

  1. MOST 106-2320-B-001-012-MY3 08/01/2017 ~ 07/31/2020 (PI)
  2. MOST 105-2320-B-001-004 08/01/2016 ~ 07/31/2017 (PI)
  3. NHRI NHRI-EX105-10521BI 01/01/2016 ~ 12/31/2018 (co-PI)
  4. MOST 103-2320-B-001-017 08/01/2014 ~ 07/31/2015 (PI)

 
PUBLICATIONS

Research papers

  1. Peng-Chan Lin, Hao-Yu Hsieh, Po-Chen Chu, and Ching S. Chen (2018, Jul). Therapeutic Opportunities of Targeting Histone Deacetylase Isoforms to Eradicate Cancer Stem Cells. International Journal of Molecular Sciences, 19(7), 1939. (IF: 3.226; SCI, 54/166, CHEMISTRY, MULTIDISCIPLINARY).
  2. Po-Chen Chu, Peng-Chan Lin, Hsing-Yu Wu, Kuen-Tyng Lin, Christina Wu, Tanios Bekaii-Saab, Yih-Jyh Lin, Chung-Ta Lee, Jeng-Chang Lee, Ching-Shih Chen (2018, Jun). Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway. Oncogene, 37(25):3440-3455. (IF: 7.519; SCI, 21/217, ONCOLOGY).
  3. Li-Yuan Bai, Chang-Fang Chiu, Shih-Jiuan Chiu, Po-Chen Chu & Jing-Ru Weng (2017, Jul). FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma cells, in part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism. Scientific Reports, 7(1):5600. (IF: 4.259; SCI, 10/64, MULTIDISCIPLINARY SCIENCES).
  4. Han-Li Huang, Hsing-Yu Wu, Po-Chen Chu, I-Lu Lai, Po-Hsien Huang, Samuel K. Kulp, Shiow-Lin Pan, Che-Ming Teng, Ching-Shih Chen (2017, Jul). Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells. Oncogenesis, 6(7):e359. (IF: 4.143; SCI, 62/217, ONCOLOGY).
  5. Wan-Chi Tsai, Li-Yuan Bai, Yi-Jin Chen, Po-Chen Chu, Ya-Wen Hsu, Aaron M. Sargeant, Jing-Ru Weng (2017, Apr). OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling. Oncotarget, 8(17):29233-29246. (IF: 5.168; SCI, 44/217, ONCOLOGY).
  6. Po-Hsien Huang, Pei-Jung Lu, Li-Yun Ding, Po-Chen Chu, Wei-Yu Hsu, Chang-Shi Chen, Chih-Chieh Tsao, Bo-Heng Chen, Chung-Ta Lee, Yan-Shen Shan, and Ching-Shih Chen (2017, Apr). TGFb promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1. Oncogene, 36(16):2202-2214. (IF: 7.519; SCI, 21/217, ONCOLOGY).
  7. Po-Chen Chu, Samuel K. Kulp, Tanios Bekaii-Saab, and Ching-Shih Chen (2016, Dec). Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer. Small GTPases, Dec 9:1-5.
  8. Po-Chen Chu, Ming-Chen Yang, Samuel K. Kulp, Santosh B. Salunke, Lauren E. Himmel, Chun-Sheng Fang, Appaso M. Jadhav, Yan-Shen Shan, Chung-Ta Lee, Ming-Derg Lai, Lawrence A. Shirley, Tanios Bekaii-Saab, and Ching-Shih Chen (2016, Jul). Regulation of oncogenic KRAS signaling via a novel KRAS integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells. Oncogene, 35(30):3897-3908. (IF: 7.519; SCI, 21/217, ONCOLOGY).
  9. Peng-Chan Lin, Yi-Fang Yang, Yu-Chang Tyan, Eric S. L. Hsiao, Po-Chen Chu, Chung-Ta Lee, Jenq-Chang Lee, Yi-Ming Arthur Chen, Pao-Chi Liao (2016, Jul). Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses. PLoS One, 11(7):e0158844. (IF: 2.806; SCI, 15/64, MULTIDISCIPLINARY SCIENCES).
  10. Chia-Hsien Wu, Li-Yuan Bai, Ming-Hsui Tsai, Po-Chen Chu, Chang-Fang Chiu, Michael Yuanchien Chen, Shih-Jiuan Chiu, Jo-Hua Chiang & Jing-Ru Weng (2016, Jun). Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents-A drug repurposing strategy. Scientific Reports, 6:27540. (IF: 4.259; SCI, 10/64, MULTIDISCIPLINARY SCIENCES).
  11. Li-Yuan Bai, Chang-Fang Chiu, Po-Chen Chu, Wei-Yu Lin, Shih-Jiuan Chiu & Jing-Ru Weng (2016, Mar). A triterpenoid from wild bitter gourd inhibits breast cancer cells. Scientific Reports, 6:22419. (IF: 4.259; SCI, 10/64, MULTIDISCIPLINARY SCIENCES).
  12. Min-Wu Chao, Po-Chen Chu, Hsiao-Ching Chuang, Fang-Hsiu Shen, Chih-Chieh Chou, En-Chi Hsu, Lauren E. Himmel, Han-Li Huang, Huang-Ju Tu, Samuel K. Kulp, Che-Ming Teng, Ching-Shih Chen (2016, Jan). Non-epigenetic Function of HDAC8 in Regulating Breast Cancer Stem Cells by Maintaining Notch1 Protein Stability. Oncotarget, 7(2):1796-1807. (IF: 5.168; SCI, 44/217, ONCOLOGY).
  13. Chi-Fang Chang#, Po-Chen Chu#, Pei-Yu Wu, Ming-Ying Yu, Jin-Yu Lee, Ming-Daw Tsai, Mau-Sun Chang (2015, Apr). PHRF1 promotes genome integrity by modulating non-homologous end-joining. Cell Death and Disease, 6:e1716. (IF: 5.965; SCI, 39/190, CELL BIOLOGY). (# Equal Contribution).
  14. Lisa D. Berman-Booty, Po-Chen Chu, Jennifer M. Thomas-Ahner, Brad Bolon, Dasheng Wang, Tiffany Yang, Steven K. Clinton, Samuel K. Kulp, and Ching-Shih Chen (2013, Mar). Suppression of prostate epithelial proliferation and lesion progression in transgenic mice by a novel energy restriction-mimetic agent. Cancer Prevention Research, 6(3):232-241. (IF: 5.021; SCI, 67/217, ONCOLOGY).
  15. Po-Chen Chu, Hsiao-Ching Chuang, Samuel K. Kulp, and Ching-Shih Chen (2012, Dec). The mRNA-stabilizing factor HuR protein is targeted by b-TrCP protein for degradation in response to glycolysis inhibition. The Journal of Biological Chemistry, 287(52):43639-43650. (IF: 4.125; SCI, 74/286, BIOCHEMISTRY & MOLECULAR BIOLOGY).
  16. Shuo Wei, Po-Chen Chu, Hsiao-Ching Chuang, Wen-Chun Hung, Samuel K. Kulp, Ching-Shih Chen (2012, Oct). Targeting the Oncogenic E3 Ligase Skp2 in Prostate and Breast Cancer Cells with a Novel Energy Restriction-Mimetic Agent. PLoS One, 7(10):e47298. (IF: 2.806; SCI, 15/64, MULTIDISCIPLINARY SCIENCES).
  17. Chia-Hsin Chen#, Po-Chen Chu#, Liekyeow Lee, Huang-Wei Lien, Tse-Ling Lin, Chi-Chen Fan, Peter Chi, Chang-Jen Huang, Mau-Sun Chang (2012, Mar). Disruption of Murine mp29/Syf2/Ntc31 Gene Results in Embryonic Lethality with Aberrant Checkpoint Response. PLoS One, 7(3):e33538. (IF: 2.806; SCI, 15/64, MULTIDISCIPLINARY SCIENCES). (# Equal Contribution).
  18. Chun-Han Chen, Po-Hsien Huang, Po-Chen Chu, Mei-Chuan Chen, Chih-Chien Chou, Dasheng Wang, Samuel K. Kulp, Che-Ming Teng, Qianben Wang and Ching-Shih Chen (2011, Mar). Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. The Journal of Biological Chemistry, 286(12):9968-9976. (IF: 4.125; SCI, 74/286, BIOCHEMISTRY & MOLECULAR BIOLOGY).
  19. Hao-Yen Chang, Chi-Chen Fan, Po-Chen Chu, Bo-En Hong, Hyeon Jeong Lee, and Mau-Sun Chang (2011, Feb). hPuf-A/KIAA0020 Modulates PARP-1 Cleavage upon Genotoxic Stress. Cancer Research, 71(3):1126-34. (IF: 9.122; SCI, 15/217, ONCOLOGY).
  20. Po-Chen Chu, Tao-Yeuan Wang, Yen-Ta Lu, Chuan-Kai Chou, Yuh-Cheng Yang, Mau-Sun Chang (2009, Oct). Involvement of p29 in DNA damage responses and Fanconi anemia pathway. Carcinogenesis, 30(10):1710-1716. (IF: 5.105; SCI, 46/217, ONCOLOGY).
  21. Po-Chen Chu, Yuh-Cheng Yang, Yen-Ta Lu, Hsiang-Ting Chen, Lung-Chih Yu, and Mau-Sun Chang (2006, Sep). Silencing of p29 affects DNA damage responses with UV irradiation. Cancer Research, 66 (17):8484-8491. (IF: 9.122; SCI, 15/217, ONCOLOGY).
  22. Mau-Sun Chang, Yen-Ta Lu, Shin-Tsung Ho, Chao-Chih Wu, Tsai-Yin Wei, Chia-Ju Chen, Yun-Ting Hsu, Po-Chen Chu, Ching-Hsin Chen, Jien-Ming Chu, Ya-Lin Jan, Chia-Chien Hung, Chi-Chen Fan, Yuh-Cheng Yang (2004, Feb). Antibody detection of SARS-CoV spike and nucleocapsid protein. Biochemical and Biophysical Research Communications, 314 (4):931-936. (IF: 2.466; SCI, 163/286, BIOCHEMISTRY & MOLECULAR BIOLOGY).

Conference papers

2017 AACR, Walter E. Washington Convention Center, Washington, D.C., USA

2014 AACR, San Diego Convention Center, San Diego, CA, USA.

  1. Hsing-Yu Wu, Ming-Chen Yang, Po-Chen Chu, Samuel K. Kulp, Ching-Shih Chen (2017, Apr). Novel function of p21-activated kinase 3 (PAK3) in regulating Akt phosphorylation and pancreatic cancer stem cell phenotypes.
  2. Po-Chen Chu, Ming-Chen Yang, Samuel K. Kulp and Ching-Shih Chen (2014, Apr). Targeting a Novel KRAS-Integrin-Linked Kinase Regulatory Circuitry in Pancreatic Cancer.

    OSUCCC-James 14th Annual Scientific Meeting, Ohio Union, Columbus, OH, USA.

    OSUCCC-James 14th Annual Scientific Meeting, Ohio Union, Columbus, OH, USA.

    2009 The Mammalian DNA Repair Gordon Research Conference, Four Points Sheraton, Ventura, CA, USA.

    • Lisa Berman-Booty, Po-Chen Chu, Jennifer Thomas-Ahner, Dasheng Wang, Tiffany Yang, Steven Clinton, Samuel Kulp, Ching-Shih Chen (2012, Mar). Evaluation of the chemopreventive activity of the novel energy restriction mimetic agent OSU-CG5 in TRAMP mice.
    • Po-Chen Chu, Da-Sheng Wang, Samuel K. Kulp, Ching-Shih Chen (2012, Mar). Downregulation of IGF-1R expression by energy restriction-mimetic agents in prostate cancer through transcriptional and post-transcriptional regulation.
    • Po-Chen Chu, Tao-Yeuan Wang, Yen-Ta Lu, Chuan-Kai Chou, Yuh-Cheng Yang and Mau-Sun Chang (2009, Feb). A novel role of p29 in DNA damage checkpoint and Fanconi anemia pathway.